Here are some notes on accessibility in game design from Henry Jenkins and Eitan Glinert (one of his students). Glinert has written a thesis on designing games that are accessible to everyone, including those with disabilities. He shares two key ideas:

"Make a game about sad."

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My favorite game is Super Smash Bros. Melee for the Gamecube. It has a lot of characters from the Nintendo franchise. The game is a fighting/action game that features all stars from many series like Super Mario Bros., and The Legend of Zelda. They pit them into an arena where they can fight using various items. Melee is the second installment of a series that made its debut on the Nintendo 64. The third installment is coming soon on the Wii, Super Smash Bros. Brawl, and its going to be even more spectacular.